titin

• tam adında 189,819 harf bulunmaktaymış.
  
  http://en.wikipedia.org/…in#linguistic_significance
• bu devasa protein, tek polipeptit yapidaki bilinen en buyuk proteindir. yaklasik 30.000 amino asit icerir ve 4 milyon dalton (4000kd) agirligindadir. kiyaslamak icin insülin'i ornek olarak kullanirsak bu dev yapı daha iyi kavranabilir; insulin proteini 51 amino asitten olusur ve ~6000 (6kd) dalton agirligindadir. ayrica titin proteinini üreten gen (ttn geni), 363 adet intron icererek, bilinen genler arasinda en cok intron iceren gendir (insulin sentezini baslatan gen yalnizca 2 intron icerir). titin, kas kasilma mekanizmasinda rol oynar ve sarkomerin ana elemanlarindandir. bu proteinin adi da zaten, buyuklugunu vurgulamak amaciyla titandan turetilmistir.
• tam adı (en azından ilk birkaç bin karakteri) şöyledir:
  
  methionylthreonylthreonylglutaminyl-
  arginyltyrosylglutamylserylleucylph-
  enylalanylalanylglutaminylleucyllys-
  ylglutamylarginyllysylglutamylglycy-
  lalanylphenylalanylvalylprolylpheny-
  lalanylvalylthreonylleucylglycylasp-
  artylprolylglycylisoleucylglutamylg-
  lutaminylserylleucyllysylisoleucyla-
  spartylthreonylleucylisoleucylgluta-
  mylalanylglycylalanylaspartylalanyl-
  leucylglutamylleucylglycylisoleucyl-
  prolylphenylalanylserylaspartylprol-
  ylleucylalanylaspartylglycylprolylt-
  hreonylisoleucylglutaminylasparagin-
  ylalanylthreonylleucylarginylalanyl-
  phenylalanylalanylalanylglycylvalyl-
  threonylprolylalanylglutaminylcyste-
  inylphenylalanylglutamylmethionylle-
  ucylalanylleucylisoleucylarginylglu-
  taminyllysylhistidylprolylthreonyli-
  soleucylprolylisoleucylglycylleucyl-
  leucylmethionyltyrosylalanylasparag-
  inylleucylvalylphenylalanylasparagi-
  nyllysylglycylisoleucylaspartylgluta-
  mylphenylalanyltyrosylalanylglutamin-
  ylcysteinylglutamyllysylvalylglycylva-
  lylaspartylserylvalylleucylvalylalany-
  laspartylvalylprolylvalylglutaminylgl-
  utamylserylalanylprolylphenylalanylar-
  ginylglutaminylalanylalanylleucylargi-
  nylhistidylasparaginylvalylalanylprol-
  ylisoleucylphenylalanylisoleucylcyste-
  inylprolylprolylaspartylalanylaspartyl-
  aspartylaspartylleucylleucylarginylglu-
  taminylisoleucylalanylseryltyrosylglyc-
  ylarginylglycyltyrosylthreonyltyrosyll-
  eucylleucylserylarginylalanylglycylval-
  ylthreonylglycylalanylglutamylasparagi-
  nylarginylalanylalanylleucylprolylleuc-
  ylasparaginylhistidylleucylvalylalanyll-
  ysylleucyllysylglutamyltyrosylasparaginy-
  lalanylalanylprolylprolylleucylglutaminy-
  lglycylphenylalanylglycylisoleucylseryla-
  lanylprolylaspartylglutaminylvalyllysyla-
  lanylalanylisoleucylaspartylalanylglycyl-
  alanylalanylglycylalanylisoleucylserylgl-
  ycylserylalanylisoleucylvalyllysylisoleuc-
  ylisoleucylglutamylglutaminylhistidylaspa-
  raginylisoleucylglutamylprolylglutamyllys-
  ylmethionylleucylalanylalanylleucyllysylva-
  lylphenylalanylvalylglutaminylprolylmethion-
  yllysylalanylalanylthreonylarginylacetylser-
  yltyrosylserylisoleucylthreonylserylprolylse-
  rylglutaminylphenylalanylvalylphenylalanylle-
  ucylserylserylvalyltryptophylalanylaspartylpr-
  olylisoleucylglutamylleucylleucylasparaginylv-
  alylcysteinylthreonylserylserylleucylglycylas-
  paraginylglutaminylphenylalanylglutaminylthreo-
  nylglutaminylglutaminylalanylarginylthreonylth-
  reonylglutaminylvalylglutaminylglutaminylphenyl-
  alanylserylglutaminylvalyltryptophyllysylprolylp-
  henylalanylprolylglutaminylserylthreonylvalylarginy-
  lphenylalanylprolylglycylaspartylvalyltyrosyllysy-
  lvalyltyrosylarginyltyrosylasparaginylalanylvalyll-
  eucylaspartylprolylleucylisoleucylthreonylalanylleu-
  cylleucylglycylthreonylphenylalanylaspartylthreonylarg-
  inylasparaginylarginylisoleucylisoleucylglutamylvalylg-
  lutamylasparaginylglutaminylglutaminylserylprolylthreony-
  lthreonylalanylglutamylthreonylleucylaspartylalanylthreon-
  ylarginylarginylvalylaspartylaspartylalanylthreonylvalylalany-
  lisoleucylarginylserylalanylasparaginylisoleucylasparaginylle-
  ucylvalylasparaginylglutamylleucylvalylarginylglycylthreonylglyc-
  ylleucyltyrosylasparaginylglutaminylasparaginylthreonylphenylalanylg-
  lutamylserylmethionylserylglycylleucylvalyltryptophylthreonylserylalan-
  ylprolylalanyltitinmethionylglutaminylarginyltyrosylglutamylserylleucyl-
  phenylalanylalanylisoleucylcysteinylprolylprolylaspartylalanylaspartylasp-
  artylaspartylleucylleucylarginylglutaminylisoleucylalanylseryltyrosylglyc-
  ylarginylglycyltyrosylthreonyltyrosylleucylleucylserylarginylalanylgl-
  ycylvalylthreonylglycylalanylglutamylasparaginylarginylalanylalanyll-
  eucylprolylleucylasparaginylhistidylleucylvalylalanyllysylleucyllysy-
  lglutamyltyrosylasparaginylalanylalanylprolylprolylleucylglutaminylg-
  lycylphenylalanylglycylisoleucylserylalanylprolylaspartylgluta-
  minylvalyllysylalanylalanylisoleucylaspartylalanylglycylalanyl-
  alanylglycylalanylisoleucylserylglycylserylalanylisoleucylvaly-
  llysylisoleucylisoleucylglutamylglutaminylhistidylasparaginylis-
  oleucylglutamylprolylglutamyllysylmethionylleucylalanylalanylle-
  ucyllysylvalylphenylalanylvalylglutaminylprolylmethionyllysylal-
  anylalanylthreonylarginylacetylseryltyrosylserylisoleucylthre-
  onylserylprolylserylglutaminylphenylalanylvalylphenylalanylle-
  ucylserylserylvalyltryptophylalanylaspartylprolylisoleucylglu-
  tamylleucylleucylasparaginylvalylcysteinylthreonylserylseryll-
  eucylglycylasparaginylglutaminylphenylalanylglutaminylthreony-
  lglutaminylglutaminylalanylarginylthreonylthreonylglutaminyl-
  valylglutaminylglutaminylphenylalanylserylglutaminylvalyltry-
  ptophyllysylprolylphenylalanylprolylglutaminylserylthreonylv-
  alylarginylphenylalanylprolylglycylaspartylvalyltyrosyllysyl-
  valyltyrosylarginyltyrosylasparaginylalanylvalylleucylaspar-
  tylprolylleucylisoleucylthreonylalanylleucylleucylglycylthr-
  eonylphenylalanylaspartylthreonylarginylasparaginylarginyli-
  soleucylisoleucylglutamylvalylglutamylasparaginylglu-
  taminylglutaminylserylprolylthreonylthreonylalanylgl-
  utamylthreonylleucylaspartylalanylthreonylarginylargi-
  nylvalylaspartylaspartylalanylthreonylvalylalanylisol-
  eucylarginylserylalanylasparaginylisoleucylasparaginy-
  lleucylvalylasparaginylglutamylleucylvalylarginylglyc-
  ylthreonylglycylleucyltyrosylasparaginylglutaminylasp-
  araginylthreonylphenylalanylglutamylserylmethionylser-
  ylglycylleucylvalyltryptophylthreonylserylalanylproly-
  lalanyltitinmethionylglutaminylarginyltyrosylglutamyl-
  serylleucylphenylalanylalanylisoleucylcysteinylprolyl-
  prolylaspartylalanylaspartylaspartylaspartylleucylleu-
  cylarginylglutaminylisoleucylalanylseryltyrosylglycyl-
  arginylglycyltyrosylthreonyltyrosylleucylleucylseryla-
  rginylalanylglycylvalylthreonylglycylalanylglutamyla-
  sparaginylarginylalanylalanylleucylprolylleucylaspar-
  aginylhistidylleucylvalylalanyllysylleucyllysylgluta-
  myltyrosylasparaginylalanylalanylprolylprolylleucylg-
  lutaminylglycylphenylalanylglycylisoleucylserylalany-
  lprolylaspartylglutaminylvalyllysylalanylalanylisol-
  eucylaspartylalanylglycylalanylalanylglycylalanylis-
  oleucylserylglycylserylalanylisoleucylvalyllysyliso-
  leucylisoleucylglutamylglutaminylhistidylasparaginy-
  lisoleucylglutamylprolylglutamyllysylmethionylleucy-
  lalanylalanylleucyllysylvalylphenylalanylvalylgluta-
  minylprolylmethionyllysylalanylalanylthreonylarginy-
  lacetylseryltyrosylserylisoleucylthreonylserylproly-
  lserylglutaminylphenylalanylvalylphenylalanylleucyl-
  serylserylvalyltryptophylalanylaspartylprolylisoleu-
  cylglutamylleucylleucylasparaginylvalylcysteinylthr-
  eonylserylserylleucylglycylasparaginylglutaminylphe-
  nylalanylglutaminylthreonylglutaminylglutaminylalan-
  ylarginylthreonylthreonylglutaminylvalylglutaminylg-
  lutaminylphenylalanylserylglutaminylvalyltryptophyl-
  lysylprolylphenylalanylprolylglutaminylserylthreony-
  lvalylarginylphenylalanylprolylglycylaspartylvalylt-
  yrosyllysylvalyltyrosylarginyltyrosylasparaginyla-
  lanylvalylleucylaspartylprolylleucylisoleucylt-
  hreonylalanylleucylleucylglycylthreonylpheny-
  lalanylaspartylthreonylarginylasparaginylargi-
  nylisoleucylisoleucylglutamylvalylglutamylas-
  paraginylglutaminylglutaminylserylprolylthre-
  onylthreonylalanylglutamylthreonylleucylasp-
  artylalanylthreonylarginylarginylvalylaspartylaspa-
  rtylalanylthreonylvalylalanylisoleucylarginylserylalan-
  ylasparaginylisoleucylasparaginylleucylvalylasparaginy-
  lglutamylleucylvalylarginylglycylthreonylglycylleucyltyr-
  osylasparaginylglutaminylasparaginylthreonylphenylalanyl-
  
  (bkz: kelimelerin kifayetsiz kalması)
• okunusunu merak edenler varsa diye bunu buraya birakiyorum:
  http://youtu.be/fx0kmiziioi
• kas yapısında bulunan çok bileşenli protein zinciri. 189.819^* harflik iupac adlandırması da şöyle.
• miyozini z çizgisine bağlayan proteindir
• titin elastik bir proteindir.sarkomerde bulunur.bir ucu ile z çizgisine tutunurken, bir ucu ile miyozin kuyruklarının birleştiği m çizgisine bağlanır.böylece miyozinin sarkomerde santral pozisyonunu sağlar.elastik yapısından dolayı sarkomerin aşırı gerilmesini önler.
• esas görevi myosin'i kastaki z çizgisi'ne bağlar. z çizgisinde ise kas hücrelerinde ara filaman olarak bulunan desmin bulunur. o desminleri birbirine bağlayan proteine plektin proteinleri bağlar. aktin'i z çizgisine bağlayan proteine
  aktinin denir. ve g aktin'leri birbirine nebulin bağlar ve f aktin'i oluşturur.
  
  oluşan bu f aktin'i hücre zarına bağlayan yapıya distrofin denir. ve bunun mutasyonunda duchenne muscular dystrophy görülür. k, bu sadece erkeklerde bulunur. çünkü x'e bağlı geçer. ve bir kas hastalığı olmasına rağmen zeka geriliği yapar.
  ( laminin eksikliğinde konjenital müsküler distrofi görülür ki bu bebekler anne karnında ölürler.)
  
  ayrıca titin insanda bilinen en büyük proteindir.
• bilinen en büyük protein. ismi 'titan'dan (satürn'ün en büyük uydusu) gelmektedir. kasların kasılma birimi olan sarkomerlerde miyozin filamentlerinin z bandına tutunmasını sağlar. kasılamaz ama esnek bir proteindir. sarkomer boyunu sabit tutmakla mükelleftir.
• çizgili kas dokularının kasılmasında önemli olan bir proteindir. sarkomerdeki z çizgisini m çizgisine bağlar.